De essentie van het connectoom
In de video's hieronder wordt de essentie van het Human Connectome programma uitgelegd.
<< The video shows the 3D reconstruction of the major long range fiber fascicles in a dynamic and aesthetic representation. The unusual close-up view from inside the brain gives new insights in the spatial relation between the different fascicles and allows a fascinating view form a new perspective. The data shows reconstructed structures from a single brain measures by diffusion MRI. The animation was produced with brainGL http://braingl.googlecode.com and used diffusion MRI tractography based on diffusion tensor imaging (DTI).
>> One of the greatest challenges in neuroscience is to identify the map of connections between neurons. In a landmark paper published in PNAS, the EPFL's Blue Brain Project (BBP) has identified key principles that determine synapse-scale connectivity by virtually reconstructing a cortical microcircuit and comparing it to a mammalian sample.
<< The Human Connectome Project, one of the most ambitious programs in all of neuroscience, has just yielded a “network map” that is shedding light on the intricate connectivity in the brain. In this video, scientists explain how they created this wiring diagram that maps both the functional and structural connections within the human brain.
>> David C. Van Essen is the Alumni Endowed Professor in the Anatomy & Neurobiology Department at Washington University in St. Louis. He has pioneered the use of surface-based analysis methods to characterize the structure, function, development, and connectivity of the cerebral cortex. He is Principal Investigator for the NIH Human Connectome Project, a large-scale effort to map brain circuitry and its relationship to behavior in healthy adults. His physiological and anatomical studies have provided deep insights into cortical functional organization. He has served as Editor-in-Chief of the Journal of Neuroscience, President of the Society for Neuroscience, and Head of the Anatomy & Neurobiology Department for 20 years. He is a fellow of the AAAS and received the Raven Lifetime Achievement Award from the St. Louis Academy of Sciences and the Krieg Cortical Discoverer Award from the Cajal Club.